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Open Access

Correction

Correction: Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells

  • Nicolas Goudin,
  • Pascal Chappert,
  • Jérome Mégret,
  • David-Alexandre Gross,
  • Benedita Rocha,
  • Orly Azogui
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Fig 5 appears incorrectly in the published article. Please see the correct Fig 5 and its caption here.

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Fig 5. DCs from PC61-depleted mice and CD4 T cells reduce the percentages of CD8 T cells expressing high level of PD-1.

(A) Histograms show cell surface expression of PD-1 on infiltrating CD8 T cells from treated and untreated tumours resected at day 14 (Left) and mean Fluorescence Intensity (MFI) of PD-1 in each group (Right). (B) CD11chiMHC IIhi tumour DCs were sorted from treated and untreated mice and cultured 3 days with naïve CD8 T cells labelled with CellTrace violet and 0.1μg/ml of anti-CD3 mAb. (C,D) Flow cytometry analysing the expression of PD-1 on dividing cells. CD11chiMHC IIhi DCs from Tumours (C) and CD11chi DCs from DLNs (D) were purified from untreated and PC61-treated mice and co-cultured 3 days with CellTrace violet-labelled CD8 T cells and in the presence or not with anti-CD3 mAb or CD4 T cells. Percentages of cells expressing PD-1 are represented in the middle of the graphs. (E,F) Histograms represent the level of PD-1 expression gated on all dividing cells according to indicated cultures. Results represent two independent experiments.

https://doi.org/10.1371/journal.pone.0171373.g001

Reference

  1. 1. Goudin N, Chappert P, Mégret J, Gross D-A, Rocha B, Azogui O (2016) Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells. PLoS ONE 11(6): e0157822. pmid:27341421

Citation: Goudin N, Chappert P, Mégret J, Gross D-A, Rocha B, Azogui O (2017) Correction: Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells. PLoS ONE 12(1): e0171373. https://doi.org/10.1371/journal.pone.0171373

Published: January 27, 2017

Copyright: © 2017 Goudin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.