Monitoring Mitochondrial Complex-I Activity Using Novel PET Probe 18F-BCPP-EF Allows Early Detection of Radiotherapy Effect in Murine Squamous Cell Carcinoma
Fig 1
Growth curves of SCCVII tumors after various doses of IR.
Tumor growth suppression by IR was shown in terms of tumor volume (Tvol) and radiation doses; 0 (non-irradiated control), 6, 15, and 30 Gy. PET scan schedule with 18F-BCPP-EF (open arrows) and 18F-FDG (closed arrows) depicts the timing of respective scans and sacrifice of animals to excise tumors for morphological study. Each point shows mean ± SD for 6 mice. Asterisk(s) indicates significant difference compared with non-treated controls on day 14, * p<0.05, ** p<0.01.