Synergistic Interaction of Light Alcohol Administration in the Presence of Mild Iron Overload in a Mouse Model of Liver Injury: Involvement of Triosephosphate Isomerase Nitration and Inactivation
Fig 7
The plausible mechanism of liver injury induced by low doses of alcohol and iron overload.
Co-exposure to alcohol and iron led to elevated NADH/NAD+ ratio and ROS/RNS, as well as low expression and activity of TIM. Oxidative/nitrative modifications of TIM caused the enzyme inactivity. The disturbed balance of NADH/NAD+ ratio and decreased expression and activity of TIM caused by a combination use of iron and ethanol, was hypothesized to favor the abnormalities in energy metabolism and hepatic lipid accumulation associated with liver disease.