Low Cytochrome Oxidase 1 Links Mitochondrial Dysfunction to Atherosclerosis in Mice and Pigs
Fig 4
Atherosclerosis and gene expressions in placebo DKO and caloric-restricted DKO mice.
Scatter plots showing plaque volume, percentage of plaque area with oxidized LDL, percentage of plaque area with macrophages, Mt-co1 and Tfam RNA expression, and titer of anti-oxidized LDL antibodies, as proxy of plasma oxidative stress in placebo (n = 12) and caloric restricted (n = 10) DKO mice. Gene expression data are ratios compared to expressions in aortic extracts of 10 C57BL/6J mice. **p<0.01 and ***p<0.001 compared to placebo DKO mice.