Neuronal Cell Death and Degeneration through Increased Nitroxidative Stress and Tau Phosphorylation in HIV-1 Transgenic Rats
Fig 9
Increased nitroxidative stress marker proteins in the hippocampus of HIV-1 Tg rats.
(A, B) Representative immunoblots of hippocampal lysates from WT and HIV-1 Tg rats with the specific antibody to 3-NT, iNOS, HIF1-α, BNIP3, p-IκB, IκB, or GAPDH, as indicated. Densitometric quantitation of each indicated protein relative to GAPDH is shown (n = 4/group). *P < 0.05. (C) Representative immunoblots of immunoprecipitated Hsp90 from WT and HIV-1 Tg rats with the specific antibody to 3-NT or HSP90 are shown to demonstrate nitration of Hsp90 in HIV-1 Tg rats.