Knockdown of Long Non-Coding RNA UCA1 Increases the Tamoxifen Sensitivity of Breast Cancer Cells through Inhibition of Wnt/β-Catenin Pathway
Fig 7
Correlation of the expression of lncRNA UCA1 and the nuclear β-catenin protein level in vivo.
(A) Immunohistochemistry staining of human breast cancer tissue shows the nuclear different β-catenin level in the different pathological stage I-IV. (B) Spearman's Rank-Order Correlation analysis for the nuclear β-catenin level and the expression of lncRNA UCA1 in human breast cancer tissues. (C) Western blot shows the nuclear protein level of β-catenin in the tumors generated from MCF-7-R (upper panel) and T47D-R (lower panel) cells with UCA1 knocked down. Lamin B served as the loading control. (D) Immunohistochemistry staining shows the nuclear β-catenin level in tumor tissues generated from MCF-7-R and T47D-R cells, respectively. Magnification, 200×. Scale bar, 100μm.