Impact of Hyperglycemia and Low Oxygen Tension on Adipose-Derived Stem Cells Compared with Dermal Fibroblasts and Keratinocytes: Importance for Wound Healing in Type 2 Diabetes
Fig 3
Impact of hyperglycemia on VEGF, SDF-1α, and KGF secretion.
DF function was altered in hyperglycemia for VEGF and SDF-1α secretions (p = 0.001), whereas ASC and Kc were not affected. Kc produced higher rates of VEGF in each condition (p<0.001 compared to ASC and DF). VEGF secretion by ASC was higher than that by DF in both glucose concentrations (p<0.001 in normoglycemia and p<0.05 in hyperglycemia). KGF secretion was not influenced by glucose concentration for the three cell types. Kc release was significantly lower than that of ASC and DF (p<0.001).