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Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice

Fig 5

Inflammatory response of bone marrow-derived macrophages from Wt and DLL4del mice.

(A) Gene expression of Dll4 was measured in BMDM of Wt and DLL4del mice. (B-C) Gene expression of Tnfα and Itgam were measured in BMDM of Wt and DLL4del mice. (D) TNFα cytokine production was measured in BMDM of Wt and DLL4del mice. (E) Wt BMDM stimulated with immobilized recombinant DLL4. All data are represented as mean +/- SEM. Data are significant at * p< 0.05, ** p< 0.01, *** p< 0.001. Significance is compared to Wt BMDM.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0167199.g005