Calcium Binding and Disulfide Bonds Regulate the Stability of Secretagogin towards Thermal and Urea Denaturation
Fig 12
Cartoon representing the free energy changes (ΔG) involved in folding and calcium binding of an EF-hand protein.
The total free energy change from its unfolded state to calcium-loaded state includes contributions from both folding and binding. Blue circles represent Ca2+ ions.