Neuronal Splicing Regulator RBFOX3 (NeuN) Regulates Adult Hippocampal Neurogenesis and Synaptogenesis
Fig 3
Rbfox3−/− mice exhibited cold hyperalgesia and impaired cognitive ability compared to WT mice.
(a) Rotarod test was performed for WT and Rbfox3−/− (KO) mice. WT, n = 8, KO, n = 8. (b) Gait analysis was evaluated for WT and KO mice. WT, n = 12, KO, n = 9. (c) Grip force test was measured for WT and KO mice. WT, n = 12, KO, n = 9. (d) Hot/cold plate test was determined for WT and KO mice. All WT mice reached a 50 s cut-off time in the cold plate test; therefore, there is no error bar for WT mice. Mann-Whitney Rank Sum Test, *P < 0.05; WT, n = 8, KO, n = 8. (e) Evaluation of prepulse inhibition test for WT and KO mice. WT, n = 12, KO, n = 9. (f) Novel object recognition test was evaluated for WT and KO mice. Student’s t-test, two-tailed, *P < 0.05, WT, n = 11, KO, n = 13.