Pdlim7 Regulates Arf6-Dependent Actin Dynamics and Is Required for Platelet-Mediated Thrombosis in Mice
Fig 1
Enhanced platelet aggregation in Pdlim7-deficient mice.
Pathological analysis of E18.5 embryo histological sections shows clumping of platelets in the aorta of Pdlim7-/- embryos (D, arrow), but not WT controls (A). Heparinized whole blood smears of Pdlim7-/- mutant and WT adult mice under bright-field illumination microscopy. Along the smear gradient in areas of higher (B, E) and lower (C, F) blood cell densities small platelets (dark purple) were distributed individually in Pdlim7+/+ mice (B, C), while the platelets in Pdlim7-/- mice demonstrate aggregation into smaller and larger clumps (E, F). Scale bars = 100 μm (A, D) and 10 μ m (B, C, E, F). Ao = aorta.