Evaluating Soluble EMMPRIN as a Marker of Disease Activity in Multiple Sclerosis: Studies of Serum and Cerebrospinal Fluid
Fig 4
sEMMPRIN in CSF: higher levels in SPMS compared to PPMS subjects.
(A) While CSF sEMMPRIN from the MS subtypes did not differ from discectomy group (3093.3–14530.0 pg/ml), the CSF sEMMPRIN from SPMS subjects (4928.4–19748.4 pg/ml) was statistically higher compared with PPMS CSF (4388.8–16614.4 pg/ml). Further, RRMS CSF sEMMPRIN levels (5617.9–15528.2 pg/ml) did not differ from other groups. Each entry represents the value from individual subjects performed in duplicate. Values are represented in pg/ml and the line data represents mean ± SEM. Groups were compared using one way ANOVA with Tukey’s post hoc test, **p<0.01. (B) Graph represents percentage of subjects in each group with sEMMPRIN levels >10,000 pg/ml. (C) Scatter plot showing correlation analysis between CSF IgG levels and sEMMPRIN in all the MS subjects. The sEMMPRIN in CSFs did not correlate with CSF IgG levels (Pearson correlation, r of -0.2382, p = 0.07).