Detecting Cooperativity between Transcription Factors Based on Functional Coherence and Similarity of Their Target Gene Sets
Fig 3
Robustness analysis of the proposed algorithm.
The average rank of the proposed algorithm using top N, where (a) N = 30, (b) N = 35, (c) N = 45, and (d) N = 50, TF pairs of the ranked list of 11325 TF pairs as the PCTFPs from the proposed algorithm. It can be seen that no matter which value of N is used, the proposed algorithm always has the smallest average rank. That is, the PCTFPs from the proposed algorithm are always more biologically meaningful than those from the 17 existing algorithms. This suggests that the proposed algorithm is robust against the number of chosen PCTFPs.