Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells
Fig 1
GWAS of inhibition of cellular proliferation by 1,25D (Imax).
(A) Manhattan plot of -log10 p-values of association of genome-wide variants with Imax. (B) Quantile-quantile (QQ) plot of distribution of observed -log10 p-values on the y-axis, versus the expected -log10 p-values on the x-axis. LocusZoom plots of the Imax GWAS associated regions in (C) chromosome 18 around rs1893662, and (D) chromosome 5 around rs6451692 (400kb windows, using 1000 genomes African populations as a reference). (E) Boxplots of Imax relative to genotypes of rs1893662 and rs6451692. Imax was corrected for age, gender, time of blood collection, batch, serum 25D levels, serum cortisol levels, and cell type proportions, and then fit to a normal distribution.