Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis
Fig 4
ANKL developed aggressively and had a low OS.
(A) Laboratory test results were monitored from the day of admission to the day of diagnosis for all three types of NK cells diseases. The significantly dynamic data reflected the rapid deterioration of the patients with ANKL compared to those with the other two disease types. * p<0.05, ** p<0.01. (B) Prognosis for the three evaluated NK cell diseases, as analyzed by the Kaplan-Meier method. The median OS for ANKL was 27 days (range, 2–1283 days), whereas that for ENKTL was 249 days (range,8–1300 days) and that for CLPD-NK was 360 days (range,180–1270 days). The mortality rate for ANKL, ENKTL, and CLPD-NK were 10.5%, 48.1% and 0% respectively. * p<0.05, ** p<0.01. (C) OS stratification by serum LDH level (＜1000 U/L vs≥1000 U/L) for the patients with ANKL, as analyzed by the Kaplan-Meier method. * p<0.05, ** p<0.01.