Subacute Changes in Cleavage Processing of Amyloid Precursor Protein and Tau following Penetrating Traumatic Brain Injury
Fig 5
Increased Aβ40 and Aβ42 7 days post-TBI.
Amyloid levels from Sham, PrI and PBBI were evaluated by chemiluminescent ELISAs 7d post-injury. (A) Quantification of Aβ40 (B) Representative visualizing of Aβ40 chemiluminescent ELISA wells. (C) Quantification of Aβ42 (D) Representative visualizing of Aβ42 chemiluminescent ELISA wells. Both Aβ40 and Aβ42 were significantly upregulated by PrI and PBBI 7d post-injury with PBBI inducing significantly more Aβ40 and Aβ42 than PrI. Statistical analysis of changes was conducted (K-W, * p<0.05; error bars: standard error of the mean, n = 10 per group).