miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis
Fig 7
Proposed relationship between miR-34 miRNAs and their targets as mediators of cellular senescence in IPF type II AECs.
p53 activation leads to up-regulation of miR-34 family of miRNAs in IPF type II AECs. Elevated miR-34a, miR-34b, or miR-34c levels lead to down-regulation of key target genes, including E2F1, c-Myc, and CCNE2, involved in the cell cycle, leading to cellular senescence.