miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis
Fig 4
qRT-PCR for miRNAs isolated from type II AECs.
Box plots of normalized relative log2 expression of miRNAs in type II AECs isolated from IPF patients (n = 15) and control subjects (n = 15). The levels of miR-34a (A), miR-34b (B), and miR-34c (C) were significantly higher in type II AECs isolated from IPF patients compared to those from control subjects (* p< 0.001 by Mann-Whitney U test). The levels of (D) miR-20a, (E) miR-29c, and (F) miR-let-7f were not significantly different in IPF patients relative to control subjects. The boxes are drawn extending from the 75th percentile to the 25th percentile. The horizontal line inside the box represents median values. The whiskers above and below the box delineate the maximum and minimum.