Remyelination Is Correlated with Regulatory T Cell Induction Following Human Embryoid Body-Derived Neural Precursor Cell Transplantation in a Viral Model of Multiple Sclerosis
Fig 3
CD4 T cell accumulation is reduced in EB-NPC-transplanted mice.
(A) Representative FACS plots demonstrating the frequency of CD4+ and CD8+ cells in the spinal cords of EB-NPC, human fibroblast, and HBSS-injected mice at day 21 pt. (B) Quantification of the frequency of CD4 and CD8 T cells. The frequency of CD4 T cells was significantly (p < 0.01) reduced in EB-NPC-transplanted animals compared to animals injected with human fibroblasts or HBSS. Data represents two independent experiments with n = 6 (EB-NPC), n = 4 (fibroblast), and n = 5 (HBSS) animals per group. Data presented as average+SEM and was analyzed using one-way ANOVA followed by Tukey’s multiple comparison test.