Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates
Fig 2
The effect of temperature and capsaicin on tail withdrawal latency.
(a) Our data show that compared to the baseline (‘Pre’), decreases in latency time (mean ± SEM, n = 8) were found after capsaicin application (‘Post’) at both temperatures and the effect of temperature was significant (F1,7 = 7.89, p = 0.026); however, there was no effect of capsaicin (F1,7 = 2.69, p = 0.145). (b) Tail withdrawal latency time measured from individual animals highlight the inter-subject variability, with two ‘non-responders’ (labelled by ‘#’ and ‘&’) identified (no response to the thermal challenge at both temperatures).