Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism

Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABA_C Receptors via Site Mutation and Partial Agonism

5-Aminovaleric acid fits in the ρ1 GABA_C orthosteric binding site in a folded conformation.

GABA (white) and 5-aminovaleric acid (red) docked in the orthosteric binding site of ρ1 GABA_C homology model based on GluCl in apo state.