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Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABA_C Receptors via Site Mutation and Partial Agonism

Fig 7

Effect of glycine, β-alanine and 5-aminovaleric acid on the GABA EC₅₀ response.

Concentration response curves of GABA EC₅₀ in the presence of (A) glycine, (B) β-alanine and (C) 5-aminovaleric acid at ρ1 WT and ρ1 T244S receptors, (Data = Mean ± SEM, n = 5).

doi: https://doi.org/10.1371/journal.pone.0156618.g007