The Corticofugal Effects of Auditory Cortex Microstimulation on Auditory Nerve and Superior Olivary Complex Responses Are Mediated via Alpha-9 Nicotinic Receptor Subunit
Fig 4
Auditory-cortex electrical microstimulation enhances the suppressive effects of contralateral noise on ABR waves I and III in WT mice, but not in alpha-9-KO mice.
This figure shows a summary of average corticofugal effects in all studied animals. Box-plots display the median and interquartile distribution of the effects of CBN in WT and alpha-9-KO mice without and with ACMS. The reference level for calculating amplitude changes in dB were the ABR amplitudes obtained without noise and without ACMS. Significant differences between WT and KO mice were obtained for CBN stimulation compared to the no noise and no ACMS condition for waves I and V (CBN effects: #p<0.05; two-way ANOVA). Significant differences were obtained for the effects of ACMS in WT mice for waves I, III and V and for wave V in alpha-9-KO mice. In addition, the effects of ACMS on wave III and V were larger for WT than for KO mice (genotype effects: *p<0.05; ACMS effects: **p<0.05; two-way ANOVA).