Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling
Fig 5
Model prediction of Wnt-pathway hyperactivation by APC inactivating mutations.
β-catenin (referred to by its official gene name CTNNB1 in the figure) token levels predicted by our model with four different APC mutations (weight on the arc going from t5 to the destruction complex (DC) set at 0.2, 0.1, 0.05 and 0, respectively). Moderate and high β-catenin stabilizations might correspond to the effects by mutations in colorectal tumor formation and the low β-catenin stabilizations might correspond to the effects by mutations in breast tumor formation.