A Plasmodium Promiscuous T Cell Epitope Delivered within the Ad5 Hexon Protein Enhances the Protective Efficacy of a Protein Based Malaria Vaccine
Fig 7
Cellular Responses induced by the vaccination regimen based on the Ad5HVRT53PyCMP vector.
CB6F1/J (n = 5 per group) mice received the regimens described in Fig 6. PBMC derived from mice whole blood were obtained during the immunization schedule on the days stated in the graph and were processed by flow cytometry, (A) CD8+ T cells able to recognize the P. yoelii CSP tetramer H-2Kd/SYVPSAEQI. (B) CD4+ T cells expressing CD49d and CD11 as markers for the differentiation of antigen experienced cells. The results are presented as the number of cells present in 106 PBMC. The differences between the groups were analyzed by Kruskal-Wallis test with Dunns post-test, significant statistical differences between the groups are denoted by *(p<0.05) **(p<0.01) ***(p<0.001).