A Model of Yeast Cell-Cycle Regulation Based on a Standard Component Modeling Strategy for Protein Regulatory Networks
Fig 2
One-parameter bifurcation diagram.
The steady-state number of ClbS molecules is plotted as a function of (fixed) cell volume. Solid line: stable steady states; dashed line: unstable steady states; blue lines: multisite phosphorylation (MultiP) model; red lines: standard component model (SCM). Both models exhibit a region of bistability between V ≈ 6 fL and V ≈ 30 fL. The right bifurcation point (at V ≈ 30 fL) corresponds to the threshold size for the Start transition.