GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer
Fig 3
GSK-3α overexpression indicates poor prognosis of lung cancer.
(A) Protein levels of GSK-3α, p-CREB, and CREB in multiple lung cancer cell lines compared with NHTBE cells. (B-D) Kaplan-Meier analysis of overall survival by low or high GSK3A (GSK3A probe set 202210_x_at) expression in (B) 1760 lung cancer patients, (C) 487 lung adenocarcinoma patients, and (D) 422 lung squamous cell carcinoma with adjuvant treatment. Overall survival analysis of the patients was performed by using Cox proportional hazard models and follow-up data for the indicated period.