Overexpression and Biological Function of Ubiquitin-Specific Protease 42 in Gastric Cancer
Fig 5
USP42 silencing inhibited cell invasion.
A. GSEA analysis in GC patients with higher USP42 expression versus lower USP42 expression based on TCGA datasets. Cell metastasis pathway was associated with USDP42-higher expression. The enrichment score (ES, green line) reflects the correlation between metastasis pathway and the sample. Black bars indicate previously known genes associated with cell metastasis pathway. B. USP42 silencing decreased cell invasion as detected by in vitro invasion assay. C, D. Expression of key proteins in metastasis and EMT was determined by western blot. * P<0.05, ** P<0.01, *** P<0.001 compared with siNC.