Diverse Basis of β-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis
Fig 3
β-catenin signaling assessed by protein expression in human HCC.
A. Representative pictures for β-catenin expression in human. B. Occurrence of β-catenin nuclear translocation in each group is shown. C. In patients with β-catenin nuclear translocation (n = 28), occurrence of β-catenin target gene upregulation in each group is shown. D. Patients with β-catenin nuclear translocation in tumor could be divided into two groups; patients with CTNNB1 mutation and without it. Furthermore, patients without CTNNB1 mutation were classified into two subgroups; patients with determined β-catenin target gene upregulation and patients without it.