The RIP1–RIP3 Complex Mediates Osteocyte Necroptosis after Ovariectomy in Rats
Fig 1
Effect of ovariectomy on rats.
(A) Changes in body weight. (B) Changes in serum CTX. (C) Changes in BMD in the proximal femur. (D) Representative photomicrographs of H&E-stained sections. The photomicrographs were obtained from OVX rats at various time points. Scale bars represent 25 μm. (E) Micro-CT evaluation of Ward’s triangle. Representative 3D reconstructed images were obtained from OVX rats at various time points. Scale bars represent 100μm. (F) BV/TV. (G) Tb.Th. (H) Tb.N. (I) Tb.Sp. The data are presented as the mean ± SEM (n = 6rats/group). #p<0.05, ##p<0.01 vs the sham group at the same time point; *p<0.05, **p<0.01 vs the OVX group at 0 weeks. Sham, sham-operated group. OVX, ovariectomy group.W,week. BMD, bone mineral density; BV/TV, bone volumefraction; Tb.Th, trabecular thickness; Tb.N, trabecular number; Tb.Sp, trabecular separation.