Regional Fluctuation in the Functional Consequence of LINE-1 Insertion in the Mitf Gene: The Black Spotting Phenotype Arisen from the Mitfmi-bw Mouse Lacking Melanocytes
Fig 6
Expression of beta-catenin and cyclin D1 in the skin tissues.
Immunohistochemical analysis of the skin tissues taken from the control transgenic mouse (A, D), the bw mouse (B, E), and the black spotting mouse (C, F) for expression of beta-catenin (A—C) and cyclin D1 (D—F) (x 100). The age of mice analyzed was 8 weeks. The expression of beta-catenin and cyclin D1 was detected in the hair follicles of the control mouse. The intensity for the expression of cyclin D1 appears highest in the epidermis of the black spotting mouse (F).