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MiR-138 Acts as a Tumor Suppressor by Targeting EZH2 and Enhances Cisplatin-Induced Apoptosis in Osteosarcoma Cells

Fig 2

miR-138 negatively regulates osteosarcoma cell proliferation, migration and invasion.

(A) (B)The Cell Counting Kit-8 (CCK-8) assay showed that MG-63 and U2OS cells stably expressing miR-138 grew slower than cells stably expressing miR-NC., (C) (D) (E) (F) Transwell migration and invasion assays of MG-63 and U2OS cells stably expressing miR-NC or miR-138 were performed.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0150026.g002