Speckle Tracking Based Strain Analysis Is Sensitive for Early Detection of Pathological Cardiac Hypertrophy
Fig 5
Characteristics of heart pathology in mice following 6-week running exercise and ISO insult.
(A, B) Heart cross-sectional HE staining showed cardiomyocytes enlarged in a uniform manner both in exercised mice and in ISO-treated mice as compared with control. (C, D) Picrosirius red staining indicated collagen deposit increased at 3 days after ISO injection but did not change following running exercise. (E) Ratio of heart weight to tibia length (HW/TL), (F) LVAW;d and (G) LVPW;d remarkably increased in mice subjected to running and ISO insult vs. control mice, suggesting both 6-week running exercise and single-dose ISO injection resulted in cardiac hypertrophy. Data are shown as mean ± SD, and one-way ANOVA is used to analyze the statistical difference among control, running and ISO insult. n = 6 per group, *P<0.05, **P<0.01, ***P<0.001, compared with control; #P<0.05, compared with running. LVAW;d, left ventricular anterior wall thickness in diastolic; LVPW;d, left ventricular posterior wall thickness in diastolic; con, control; ISO, isoproterenol.