Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms
Fig 1
Structures of derquantel and abamectin.
A: Structure of derquantel. B: Structure of abamectin. Abamectin is a mixture of avermectin B1a and avermectin B1b. Avermectin B1a differs from avermectin B1b by a functional group at the ‘R’ position, and makes up more than 80% of abamectin, while avermectin B1b makes up less than 20% of abamectin.