CERENA: ChEmical REaction Network Analyzer—A Toolbox for the Simulation and Analysis of Stochastic Chemical Kinetics
Fig 6
Simulation results for the JAK-STAT signaling pathway.
(a) Schematic of the simplified JAK-STAT signaling pathway. The intermediate states npSTAT1 to npSTAT5 are used to model the delayed export of STAT from the nucleus. (b) The mean (left) and variance (right) of dimerized phosphorylated STAT concentration, obtained using several methods. SSA simulation results serve as the reference solution.