What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue
Fig 6
Gene signature derived from SC predicts poor outcome in CRC patients.
(a-b) An overlap of 8 commonly up-regulated genes for patient and cell line-derived SC (listed in S6 Table) predicts for overall survival in CRC. (b) The combined expression of two genes, CDA & GSTA4, is linked to an increased risk of disease relapse. The number of patients in each group is mentioned within the brackets; significant p-value is indicated.