Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T84 Human Intestinal Epithelial Cells
Fig 2
The overall transmembrane H+ flux rates (JH+) were calculated from initial rates of pHi recovery and the intrinsic buffer capacity (βi) values (see Methods). A, T84 cells were exposed to culture medium without (–, Control) or with (+) 0.25 μmol/L heat-stable (STa) enterotoxin, 25 μmol/L HOE-694, or both (see Methods). B, T84 cells were exposed to increasing concentrations of STa in the presence of 25 μmol/L HOE-694 as in A. In A, *P<0.05 versus Control, †P<0.05 versus STa or HOE-694. In B, *P<0.05 versus Control, †P<0.05 versus other values in STa + HOE-694. Values are mean ± S.E.M. (n = 25–27).