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Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons

Fig 4

Effect of depression on the neuron dynamics at a high spiking stimulation frequency.

The stimuli arrives through a dynamic synapse with g_d = 1.0mS and . Input consists of sequences of bursts with 6 spikes each delivered at 1Hz and with an intraburst spiking frequency of 45Hz. This corresponds to the regions of the input/output activity maps highlighted in yellow in Fig 3C. (A) Time series showing the postsynaptic neuron activity for different levels of synaptic depression as indicated by the value of τ_rec. Grayed areas correspond to the stimulation periods. Dashed lines provide a fixed voltage reference (firing threshold for τ_rec = 0.02ms) to compare firing threshold changes under the effect of synaptic depression. Note that the firing threshold changes for different depression levels, but also dynamically for the same τ_rec value (cf. the spike before the arrow and following oscillations in the blue trace). (B-D) Dependence of mean spiking frequency, mean subthreshold frequency and mean subthreshold amplitude of the postsynaptic neuron on the depression level. Mean data are calculated in 180s time series recorded 10s after the beginning of the stimulation using a sliding window comprising two stimulation episodes in the dynamic channel. (E) Normalized power spectra corresponding to the time series depicted in panel A identified by the same color code. Blue arrows indicate the peak corresponding to the intraburst stimulation frequency.

doi: https://doi.org/10.1371/journal.pone.0145830.g004