Delivery of a Chlamydial Adhesin N-PmpC Subunit Vaccine to the Ocular Mucosa Using Particulate Carriers
Fig 9
Guinea pigs were immunized with N-PmpC EcN BGs and plain EcN BGs via the conjunctiva and subcutaneously, on days 0, 14 and 28 (50 μg BGs per dose) and two weeks after the completion of the specified immunization protocol were challenged by the ocular administration of 1 x 106 IFU/animal.
The animals were visually assessed and scored on a daily basis. Results are presented as mean pathology score ± SD at defined time point for all animals within a group (n = 5 per group).