microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements
Fig 7
siRNA-mediated depletion of WASL or ITGAV reduces matrigel invasiveness of MCF-7 and MDA-MB-231 cells.
(a) Confirmation of successful siRNA knockdown of ITGAV (left panel) and WASL (right panel) by qPCR. N = 4, ***P<0.001. (b) Confirmation of successful siRNA knockdown of integrin-αV and WASL at the protein level by Western blotting. See Fig 3E–3G for details. (c) ITGAV and WASL-depletion reduces matrigel invasiveness of MDA-MB-231 and MCF-7 cells. N>5, #P = 0.06 (n.s.), *P<0.05, ***P<0.001.