An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats
Fig 1
An atherogenic Paigen-diet worsens the nephropathy of OLETF rats.
Time-dependent changes in urine albumin excretion (A), semi-quantitative analyses of glomerular sclerosis (B) and plasma lipids and glucose concentrations (C) 12 weeks after starting to feed chow or an atherogenic diet, presented as mean ± SD. There were five animals in the following groups: LETO rats fed normal chow (LETO-NC) and Paigen diet (LETO-PD), and OLETF rats fed NC (OLETF-NC) and Western diet (OLETF-WD); and nine in the OLETF rats fed PD (OLETF-PD) groups. *p < 0.05; **p < 0.01; ns, not significant vs OLETF-NC group among three OLETF groups by Dunnett’s test. #p < 0.05; ##p < 0.01; NS, not significant by unpaired t-test. There were no significant differences between LETO-NC and LETO-PD or LETO-NC and OLETF-NC groups in urine albumin (unpaired t-test). TC, total cholesterol; TG, triacylglycerol.