Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling
Fig 2
Designing SHARPIN mutants using a SHARPIN UBL domain model.
(A) Superposition of the SHARPIN UBL domain model backbone (purple) with the UBL domain of HOIL1L (Green, PDB accession code: 4DBG). (B) Surface representation of the SHARPIN UBL model. The surface is color-coded according to residue hydrophobicity from light to deep purple. Footprints of residues mutated in this study are indicated as green outlines. (C) Alignment of part of the SHARPIN UBL domain across different species. Conserved residues mutated in this study are indicated in red.