IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome
Fig 5
Schematic model of IL6 modulation of cccDNA transcription.
STAT3, HNF1α and HNF4α bind the cccDNA and contribute to activate the transcription of cccDNA (middle). IL6 treatment results in the hypo-acetylation of cccDNA-bound histones and inhibits HBV transcription through the combined effect on HNF1α and HNF4α protein levels and a lower recruitment of P-STAT3 to the cccDNA, as compared to cellular promoters (i.e. Haptoglobin).