Gene Network Rewiring to Study Melanoma Stage Progression and Elements Essential for Driving Melanoma
Fig 7
A. Comparison of Intra-Modular (IM) sub-network density for every over-represented pathway in each melanoma stage (color: black) vs normal stage (color: red). It may be observed that the density of connections among disease genes in enriched sub-networks, generated from normal stage, decreases with disease progression. B. Conservation of enriched pathways from disease genes across different melanoma stages. C. Box-plot representing range of calculated R-scores for every pathway in each stage. High R-score implies higher dysregulation in the connectivity pattern of pathway disease genes in perturbed network as compared to the normal network. D. A combined bar and line graph representing gene count and calculated R-score of the three most common melanoma associated pathways. MAPK pathway decreased R-score is lowered after CM to LN transition despite increase in enriched gene count, whereas, other two pathways show consistent R-score irrespective of gene count.