Topoisomerase 2 Alpha Cooperates with Androgen Receptor to Contribute to Prostate Cancer Progression
Fig 3
Sensitivity of TOP2A overexpressing cells to combination treatment with TOP2A poison and anti-androgen.
A) Survival of TOP2A clones of early passage in response to combination treatment: top panel- constant dose of doxorubicin and increasing concentrations of casodex; bottom panel-constant dose of casodex and increasing concentrations of doxorubicin. B) Survival of TOP2A clones of late passage in response to combination treatment, drugs and concentrations are as in a. Data are presented as mean ± SD, based on 3 independent experiments. P values are as indicated, n.s. is not significant.