Adenomatous Polyposis Coli Mutation Leads to Myopia Development in Mice
Fig 4
Diminished tyrosine hydroxylase (TH) retinal expression in P84 APCMin mice.
(Panels A and B). TH immunostaining of eye sections of WT (A) and APCMin mice (B), showing decreased TH in the sub retinal space of APCMin mice. The nucleus was counterstained with 4, 6-diamidino-2-phenylindole (DAPI) (blue). C, Fifty micrograms of retinal protein was used for western blot analysis of TH. D, Protein levels were semiquantified with densitometry, normalized by β-actin levels, and compared between APCMin mice and WT mice littermates (mean ± SD, n = 5), ** P< 0.01.