Estrogen Receptor (ER)-α36 Is Involved in Estrogen- and Tamoxifen-Induced Neuroprotective Effects in Ischemic Stroke Models
Fig 6
Tamoxifen (TAM) promotes ER-α36 expression to mediate E2β-induced neuroprotection.
(A) The neuroprotective effect of TAM in hippocampal CA1 neurons following MCAO. OM stands for ovariectomy with middle cerebral artery occlusion. Scale bar = 50 μm (400×). (B) ER-α36 expression in rat hippocampal CA1 neurons after TAM treatment. Scale bar = 200 μm (200×). *p < 0.05, **p < 0.01 vs. sham group; #p < 0.05 vs. DMSO group.