Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs
Fig 3
Overlay of Common and Subclade-specific Motifs on Human SLC22A6 2D Topology.
(A) SLC22 family-conserved motifs versus subclade-conserved motifs. Overlaid on the 2D topology are the 16 evolutionarily-conserved family motifs (green/dark green) and the 11 subclade-specific motifs (red/blue). Conserved family motifs are assigned letters A-P in the order of appearance in human OAT1 (human SLC22A6). Subclade-specific motifs are either whole or partial (red/blue) and are assigned the numbers 1–11. (B) This table describes the order, region, and percent present of the motifs which appear in the inputted set, MEME#, E-value, and amino acid sequence of each of the subclade-specific motifs identified for the hOAT1 sequence (red). (C) This table describes the SLC22 family-conserved motifs that have been overlaid onto the hOAT1 sequence (green). It lists the motif letter and percent present in all 111 sequences used in the MEME analysis, the MEME#, E-value, and the amino acid sequence of hOAT1 associated with the particular motif letter. Additional sequence information can be found in S3 and S4 Tables.