Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs
Fig 2
Shared Motifs of SLC22 Family Transporters by MEME Analysis on 16 of the Sequences Used in the Analysis.
Abbreviations of the SLC22 member number is on the far left (e.g., A15 = SLC22A15) and known common names are on the far right. In green are the SLC22 family-conserved motifs which are lettered (A-P) in the order that they appear in the SLC22A6 amino acid sequence. The majority of the sequences follow this motif order. In red are the subclade-specific motifs overlaid on the same 1D representation of each SLC22 sequence. The first box labeled the Large Extracellular Loop represents the predicted Large Extracellular Loop [56] and the second box labeled the Large Intracellular Loop represents the predicted Large Intracellular Loop. Note that each 1D representation is proportionally scaled such that each sequence length can be estimated in the scale near the bottom of the figure.