A Nano-MgO and Ionic Liquid-Catalyzed ‘Green’ Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51)
Table 1
Cyclocondensation of 5-Phenyl-2-amino-1,3,4-thiadiazole (2) with 1-Adamantyl bromomethylketone (1) under various reaction conditions to form title compounds.
It can be seen that using nano-MgO as a base and employing ionic liquids instead of traditional organic solvents considerably increase yields above 90%.